eng Science and Education Publishing American Journal of Pharmacological Sciences 2327-672X 2022-07-19 10 1 20 25 10.12691/ajps-10-1-4 AJPS20221014 article Kouao Augustin Amonkan 1 Brou Andr¨¦ Konan andrebroukonan@gmail.com 1 Kacou Jules Marius Dj¨¦touan 1 UPR-Nutrition and Pharmacology, Laboratory of Biology and Health, UFR-Biosciences, F¨¦lix Houphou?t-Boigny University, Abidjan, C?te d¡¯Ivoire The roots of Ficus exasperata Valh (Moraceae) are commonly used in traditional medicine to treat various pathologies including edema and arterial hypertension. Also, this study was conducted to assess the effects of two extracts of the root bark of this medicinal plant on urinary excretion in rats. To do this, 12 groups of 6 water-overloaded rats (50 ml/kg) were treated separately with 0.9% NaCl solution, FURO 5 mg/kg, FEae (15-100 mg/kg) and FEee (15-100 mg/kg). Excreted urine was collected at regular intervals of 2 h for 8 h to determine urinary excretion volume (UEV). Like furosemide, the two plant extracts (FEae and FEee) caused significant urinary excretion in water-overloaded rats. The most marked effect in terms of UEV was observed after the administration of FEae 15 mg/kg. At this dose, an EUV of 76 ± 0.21% and higher than that of FURO 5 mg/kg (59 ± 0.01%) was obtained 6 h after the treatment of the animals. These recorded EUV values were significantly higher at p < 0.001 than that of 0.9 % NaCl saline solution. Ficus exasperata root bark extracts induced significant increases in urinary excretion in Wistar rats. These results could justify the empirical use of this plant as a diuretic in the treatment of edema and hypertension. However, in order to better understand the physiological mechanisms underlying this action, additional studies must be carried out. http://pubs.sciepub.com/ajps/10/1/4/ajps-10-1-4.pdf Ficus exasperata furosemide diuretic urinary excretion arterial hypertension edema