Science and Education Publishing American Journal of Pharmacological Sciences 1 1 2013 -1 29 Screening of the Anticonvulsant Activity of Some Isatin Derivatives in Experimental Seizure Models and Its Effect on Brain GABA Levels in Mice 42 46 EN Venkateshwarlu Eggadi Umasankar Kulandaivelu Sharvanabhava B S Venkateshwar Rao Jupally TallaPadmavathi College of Pharmacy, Orus, Warangal, India AJPS2013133 10.12691/ajps-1-3-3 2012 12 28 2013 -1 27 2013 -1 29 The modern therapeutic approaches of antiepileptic agents against epileptic patients are showing many side effects, dose related effects and chronic toxicity. The aim of our present work is to evaluate anticonvulsant activity of isatin derivatives (Ia-Ij) to reduce the side-effects and increase the percentage protection from various stages of convulsions. No animals showed toxic effects even up to 2000mg/kg. It is evident that Ib, Ie, Ih, Ii and Ij showed anticonvulsant effect at the dose levels of 10 and 100mg/kg in MES test and except Ij all other derivatives exhibited antiepileptic effect at 10 and 100mg/kg in PTZ induced convulsions test. The isatin derivatives(Ib, Ie, Ih and Ii) which proved antiepileptic effect in both MES and PTZ induced convulsion models are selected and GABA levels in brain were estimated. They showed significant increase of GABA levels in brain.