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American Journal of Public Health Research
DOI: 10.12691/ajphr-1-1-3

The Implementation of a Tele-Homecare System with Service Oriented Architecture and HL7 Message Transmission Standard
Ching-Sung Wang

American Journal of Medical and Biological Research
DOI: 10.12691/ajmbr-1-1-2

The Influence of Ethanol on Pyruvate Kinases Activity in Vivo, in Vitro, in Silico
Lelevich Sergey Vladimirovich, Khrustalev Vladislav Victorovich, Barkovsky Eugene Victorovich, Shedogubova Tatyana Aleksandrovna

American Journal of Medical Sciences and Medicine
DOI: 10.12691/ajmsm-1-1-1

Clinical and Histological Features in Wegener Granulomatosis
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo, Rotolo Ugo

American Journal of Infectious Diseases and Microbiology
DOI: 10.12691/ajidm-1-1-2

The Curse of Lymphatic Filariasis: Would the Continual Use of Diethylcarbamazine Eliminate this Scourge in Papua New Guinea?
Anne Lanham, Lillian Mwanri

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Will Precision Medicine Ever be A Possibility for Controlling Tuberculosis?

Somchai Bovornkitti

The Academy of Science, The Royal Society of Thailand

Abstract:

Keywords:

Citation: Somchai Bovornkitti, Will Precision Medicine Ever be A Possibility for Controlling Tuberculosis?. American Journal of Public Health Research, 6 (2). 62-62. January 2018. doi:10.12691/ajphr-6-2-7

Not long ago, the global epidemic of tuberculosis, the so-called “white plaque” was controlled by energetic medical practice. i.e., providing B.C.G. vaccination for newborns, as well as early diagnosis and proper treatment of infected persons. Unfortunately, though, recent episodes of tuberculosis have notably re-emerged and cases of chemotherapeutic resistance are prevailing. [1].

The reasons for such incidents have been sorted out and are as the follows :

(1) Epidemics of drug-resistant causative agents;

(2) Withering enthusiasm for controlling the disease, such as lagging public health activity in provision of B.C.G. vaccination, and in energetic therapeutic practice thereby, leaving cases of drug resistance and treatment failure to become drastic sources of infection; and,

(3) The inability to radically eradicate the infection, as compared to leprosy and smallpox.

Regarding public health activity, apart from revision in general practices, and/or seeking new inventions, new philosophies apply. Owing to the advances in molecular or genomic medicine, new fronts are open for “precision medicine” to target a variety of diseases, including microbial infections, such as tuberculosis, at molecular levels.

In the case of tuberculosis, this decision is based on the knowledge of innate resistance, susceptibility and possibly acquired factors that exist. [2,3,4,5,6,7,8] In this regard, the mutated portions, or any malicious genes if present in the DNA helix strands, may possibly be removed by molecular technology, such as the CRISPR/Cas system [9,10]. The named practices can be instituted prenatally or at subsequent occasions as necessitated.

References

[1]   | Bovornkitti, S. Tuberculosis situation in Thailand is deteriorating! Thammasat Medical Journal, 17: 669. 2017.
[2]   | Pitukpakorn, M., Bovornkitti, S. Molecular Medicine. Buddhachinaraj Medical Journal, 33: 246-254.2016
[3]   | Pitukpakorn, M., Bovornkitti, S. Susceptibility factors in the genesis of mesothelioma. Buddhachinaraj Medical Journal, 33: 255-257. 2016.
[4]   | Huang, S.X.L., Jaurand, M.C., Kamp, D.W., Whysner, J., Hei, T.K. Role of mutagenicity in mineral fiber-induced carcinogenicity and other diseases. Journal of Toxicology and Environmental Health, 14(Part B): 179-245. 2011.
[5]   | Li, C.M., Cambell, S.J., Kumararatne, D.S., Bellamy, R., Ruwende, C., McAdam, K.P.W.J., et al. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. The Journal of Infectious Diseases, 186 (10) : 1458-1462.2002
[6]   | Yim, J-J., Lee, H.W., Lee, H.S., Kim, Y.W., Han, S.K., Shim, Y-S., Holland, S.M. The association between microsatellite polymorphisms in intron II of human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes and Immunity, 7: 150-155. 2006.
[7]   | Azad, A.K., Sadee, W., Schlesinger, L.S. Innate immune gene polymorphisms in tuberculosis. Infection and Immunity, 80 (10) : 3343-3359. 2012.

[8]  
Blischak, J.D., Tailleux, L., Myrthil, M.,Charlois, C., Bergot, E., Dinh, A., et al. Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells. Scientific Reports 7, Article number: 5702(2017). [online] Available at: https//www.nature.com/articles/s41598-017-05878-w. [Accessed 16 November 2017].

[9]   | Pitukpakorn, M., Bovornkitti, S. Molecular Scissors. Buddhachinaraj Medical Journal, 33: 241-243.2016.
[10]   | Pitukpakorn, M., Bovornkitti, S. CRISPR/Cas: The Molecular Scissors. Thammasat Medical Journal, 17: 458-461. 2017.