eng Science and Education Publishing American Journal of Public Health Research 2327-6703 2017-06-08 5 2 43 49 10.12691/ajphr-5-2-3 AJPHR2017523 article Negasa Eshete Soboksa yeroosaa@gmail.com, freegetch01@yahoo.com 1 Getachow Nenko Yimam yeroosaa@gmail.com, freegetch01@yahoo.com 1 Public Health Department, Dilla University, Dilla, Ethiopia Background: Provision of good and consistence sanitation practice plays an essential role in protecting human health to prevent communicable diseases. The aim of this study was to assess household level sanitation practice of mothers' and associated factors in Gedeo Zone, South Ethiopia. Methods: Community based cross-sectional study design was conducted in Gedeo Zone, South Ethiopia. 634 systematically selected mothers were included in the study. Data was collected using structured questionnaire and entered into SPSS version 20.0 for analysis. Descriptive statistics were computed and logistic regression model was used to identify factors associated with outcome variable. Result: In the study only about 12.5% mothers were good sanitation practice. Majority of the mothers' in the households, (68%) had shared toilet facility and almost all were simple traditional pit without a slab. From those mothers' in the households with toilet facility, hand washing practices after critical period was reported to be 44.2%. Current study revealed that ethnicity, presence of hand washing near the latrine, source and protection of source of water supply had shown significant association. Conclusion: sanitation practice by mothers at household level in the study area was low. So health workers must pay special attention to improve this problem. http://pubs.sciepub.com/ajphr/5/2/3/ajphr-5-2-3.pdf sanitation practice mothers household level