Science and Education Publishing American Journal of Public Health Research 2327-6703 3 2 2015 03 01 Systemic Lupus Erythematosus: some Epidemiological and Clinical Aspects 46 50 EN Angel Justiz-Vaillant Department of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago Patrick E. Akpaka Peter Poonking AJPHR2015322 10.12691/ajphr-3-2-2 2015 01 29 2015 02 20 2015 03 01 Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with a wide array of clinical manifestations including rash, photosensitivity, oral ulcers, arthritis, serositis, glomerulonephritis among others clinical findings. In this paper we globally summarized the most important epidemiological and clinical aspects to bear in mind, when the time comes to make the diagnosis of this rheumatic disorder and its management. Factor that are involved in the SLE pathogenesis and novel treatment options are mentioned.