eng Science and Education Publishing American Journal of Public Health Research 2327-6703 2015-03-01 3 2 46 50 10.12691/ajphr-3-2-2 AJPHR2015322 article Angel Justiz-Vaillant Angel.Vaillant@sta.uwi.edu 1 Patrick E. Akpaka 1 Peter Poonking 2 Department of Paraclinical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago San Fernando General Hospital, San Fernando, Trinidad and Tobago Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with a wide array of clinical manifestations including rash, photosensitivity, oral ulcers, arthritis, serositis, glomerulonephritis among others clinical findings. In this paper we globally summarized the most important epidemiological and clinical aspects to bear in mind, when the time comes to make the diagnosis of this rheumatic disorder and its management. Factor that are involved in the SLE pathogenesis and novel treatment options are mentioned. http://pubs.sciepub.com/ajphr/3/2/2/ajphr-3-2-2.pdf systemic lupus erythematosus epidemiology prevalence incidence mortality immunology