@article{ajphr20231126,
author={{Nwachukwu, Chinyerem Cynthia and Njelita, Ifeoma Anne and Eyisi, Gabriel Ifeanyi and Ezenyeaku, Chijioke Amara and Nwachukwu, Amaechi Chinedu and Okechi, Obioma and Agbata, Anthony},
title={Treatment Outcomes for HIV Patients on Three HAART Regimens in South East Nigeria: A Comparative Study},
journal={American Journal of Public Health Research},
volume={11},
number={2},
pages={75--83},
year={2023},
url={http://pubs.sciepub.com/ajphr/11/2/6},
issn={2327-6703},
abstract={Human Immunodeficiency Virus (HIV) attacks the body¡¯s immune system and is responsible for a major public health problem. Highly Active Anti-Retroviral Therapy (HAART) is key to its management. This study aimed at evaluating and comparing the clinical and virological outcomes of three HAART regimens - TLD, TLE and TL/LPV/r. Number of participants was 330 patients (110 in each group). Data were analysed and compared between groups. A 5-parameter scoring system was used to compare the performance of the regimens. Overall mean age was 44.7 (¡À10.7) years. Normal BMI 138 (41.8%), overweight (33.3%), obese (20.9%) and underweight (3.9%). Normal hemoglobin level, 194 (58.8%). Mean baseline CD4 count was 389.9 ¡À 293.7. Adherence to TLD (90.0%), TLE (89.1%), TL/LPVr (62.7%). TLD group showed the most clinical improvement with the most patients in stage 1 after one year, 108 (99.1%). Viral suppression at 6 months for TLD (86.4%), TLE (86.4%), TL/LPVr (50.0%) and at 12 months, TLD (90.0%), TLE (91.8%), TL/LPVr (88.2%). The difference in viral suppression between the TLD/TLE and TL/LPVr groups was statistically significant (p < 0.001). Factors associated with WHO clinical stage 1 at 6 months were age ¡Ý35 years with TLD and female sex for TLE; and with viral suppression at 6 months were good adherence with TLD and TL/LPVr and female sex with TLE. For all patients collectively, good adherence was significantly associated with viral suppression at 6 months and 1 year. Predictor of WHO stage 1 at 6 months was female sex, OR 0.483 (95% CI 0.238 ¨C 0.980). For predictors of viral suppression at 6 months, good adherence had the highest odds ratio, OR 6.911 (95% CI 3.768 ¨C 12.676), being currently married OR 1.826 (95% CI 1.036 ¨C 3.217). TLD performed best with a score of 14, TLE 13, TL/LPVr 5, out of a maximum score of 15.},
doi={10.12691/ajphr-11-2-6}
publisher={Science and Education Publishing}
}