eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2020-11-15 9 1 1 7 10.12691/ajnr-9-1-1 AJNR2021911 article Awad Hassan Alkhatib Alkhatib.a@Kamc.med.sa 1 Ebtisam Abdullatif Ibrahim 2 Mohammed Ameenuddin 2 Ibrahim Abdullatif Ibrahim 3 Critical care unit, King Abdullah Medical City, Makkah, Saudi Arabia Nursing research department, King Abdullah Medical City, Makkah, Saudi Arabia Nursing administration department, Faculty of nursing, Mansoura University, Mansoura, Egypt Background: Health care organizations consider evidence-based practice as the gold standard for the provision of safe and compassionate health care. Aim of the study: The present study aims to assess the knowledge, perception, and attitude of nurses regarding evidence-based practice. Subjects and Methods: A descriptive design was utilized to achieve the aim of the study. The study included a random sample of (262) staff nurses who were responsible for providing nursing care to patients. Data were collected using three scales; knowledge scale, perception scale, and attitude scale regarding evidence-based practice. Results: The majority of the studied nurses had the knowledge and negative attitude regarding evidence-based practice and two-third of the studied nurses had a moderate level of perception regarding evidence-based practice. There was a statistically significant relationship between nursesĄŻ knowledge and their educational qualification and there was a statistically significant relationship between nursesĄŻ perception and their gender, educational qualification, and experience. Conclusion: There was a significant relationship between nursesĄŻ Knowledge, perception, and attitude towards evidence-based practice. Recommendations: Nursing managers should develop an evidence-based practice training program to help nurses to be familiar with EBP steps. Nursing managers should motivate the nurses who follow up the EBP with different incentives. http://pubs.sciepub.com/ajnr/9/1/1/ajnr-9-1-1.pdf attitude evidence-based practice knowledge nurses perception