eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2020-02-11 8 2 269 277 10.12691/ajnr-8-2-16 AJNR20208216 article Samia I Hassan 1 Ahlam Mohammed Ibrahim Gouda 1 Ahmed El-Monshed 2 Hanan Abderahman Mostafa Kandeel 3 Woman's Health & Midwifery, Nursing Department, Faculty of Nursing, Mansoura University, Egypt Psychiatric and Mental health Nursing Department, Faculty of Nursing, Mansoura University, Egypt Obstetric and Gynecologic Nursing, Faculty of Nursing, Alexandria University, Egypt Aim: Investigate the effect of cognitive behavioral therapy on anxiety, stress, depression, and coping pattern among pregnant with pre- eclampsia. Method: Design: Quazi experimental (pre and posttest) design. Setting: Antenatal outpatient clinic and high-risk inpatient department in Mansoura University Hospital. Subjects: Eighty six pre- eclamptic women who attending antenatal outpatient clinic, and high risk inpatient department, Mansoura University Hospital, subjects were divided randomly into two equal groups. Types of sampling: purposive sample. Tools: Five tools were used for data collection, structured interview schedule, Beck Anxiety Inventory, Perceived stress scale (PSS), Beck depression inventory-II (BDI-II) and Coping Patterns Scale. Results: The study findings revealed that there was a statistical significant difference in scores of depression, anxiety, and stress pre and post the cognitive behavioral therapy among the intervention group (P¡Ü0.001) with large effect size (¦Ç2=0.7). Conversely, in the control group, there was no statistical difference in scores of depression, anxiety, and stress pre and post the routine care (P>0.05). Conclusion: Cognitive-behavioral therapy can be used as a treatment option for reducing pregnancy-specific anxiety, stress and depression in preeclamptic women. Also, improve coping pattern among high risk pregnant women. Recommendations: Involvement of CBT among routine hospital care especially in a high risk unit. http://pubs.sciepub.com/ajnr/8/2/16/ajnr-8-2-16.pdf anxiety cognitive behavioral therapy coping pattern depression preeclampsia and stress