eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2020-01-10 8 2 132 141 10.12691/ajnr-8-2-1 AJNR2020821 article Wafaa Mostafa Ahmed Gamel 1 Amal Sarhan Eldesokey Genedy 1 Hanan Elzeblawy Hassan nona_nano_1712@yahoo.com 2 Maternal and Neonatal Health Nursing Department, Faculty of Nursing, Fayoum University, Egypt Maternal and Newborn Health Nursing Department, Faculty of Nursing, Beni-Suef University, Egypt Background: Over 30.000 maternal deaths were referred to as postpartum sepsis; which consider as the third most frequent cause of approximately 290.000 maternal deaths worldwide. Puerperal sepsis is an important public health problem which is а leading cause of maternal death, especially, in developing countries due to the lack of knowledge on preventive methods. This study aimed to investigate the impact of puerperal sepsis self-care nursing guidelines on women's knowledge and practice among primiparous postnatal mothers. Subjects and Methods: An interventional quasi-experimental, pre-posttest, research design was carried out at the postpartum unit of Fayoum General and University Hospitals on 100 primiparous women. Data were collected using a structured interview questionnaire. Results: There is a highly significant improvement of the studied women’s knowledge regarding puerperal sepsis after introducing of the puerperal sepsis self-care-nursing-guidelines compared with pre-intervention (p<0.001). There are no significant differences in the total score of knowledge about socio-demographic variables (p>0.05). However, improvement of women’s knowledge regardless of their demographic variables was noticed in both immediately-intervention and one-month after the intervention. Conclusion: The primiparous-postnatal mothers who received and compliance with the guidelines regarding puerperal sepsis and its prevention had high knowledge and practices score in the post-test of the intervention program than in pre-test (P≤0.01), which shows the effectiveness of puerperal sepsis self-care nursing guidelines in increasing the knowledge score of primiparous post-natal mothers regarding the prevention of puerperal sepsis. Recommendations: Such guideline needs to be given while the antenatal period also and thus promote healthy post-partum period. The study can be replicated in a larger sample, in different settings. http://pubs.sciepub.com/ajnr/8/2/1/ajnr-8-2-1.pdf puerperѧl sepsis self-cѧre nursing guidelines knowledge and prѧctices