eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2019-10-29 7 6 1057 1068 10.12691/ajnr-7-6-20 AJNR20197620 article Samah El Awady Bassam Awady@yahoo.com 1 Pediatric Nursing Department, Faculty of Nursing, Zagazig University, Egypt Background: Puberty is a period of rapid growth and hormonal changes and is often characterized by deterioration in glycemic control, and all of these factors may promote the development of diabetes complications. Type 1 diabetes mellitus (T1DM) is a chronic disease requiring complex management, including blood glucose monitoring, insulin administration along with diet restrictions, which can have a negative impact on the quality of life (QoL) of adolescents. The aim of the study: This study aimed to investigate the relationship between compliance and quality of life among adolescents with diabetes mellitus type 1. Design: A descriptive cross-sectional design was utilized in this study. Setting: This study was conducted at the outpatient clinics in Zagazig University Hospitals at the pediatrics unit and the health insurance clinic for diabetes in Zagazig city. Subjects: A convenient sample of 80 adolescents diagnosed with type 1 diabetes Three tools were used for data collection, namely; A structured interviewing questionnaire, Diabetes self-management profile, and Diabetes quality of life for youths scale. The results: Slightly more than half of adolescent had a moderate knowledge of diabetes mellitus (53.8%), the highest percentage of the study sample had inadequate levels of compliance to diabetes treatment recommendations and perceived their quality of life as low (61.3% & 67.5%, respectively). Conclusion: It was found that there was a statistically significant relation between adolescents' compliance and quality of life score. Recommendations: Conduct educational program for adolescents and their parents to increase the level of their knowledge and compliance for diabetes management to improve QOL for all diabetic adolescents. http://pubs.sciepub.com/ajnr/7/6/20/ajnr-7-6-20.pdf adolescents compliance diabetes mellitus type 1 quality of life