eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2019-05-17 7 4 453 464 10.12691/ajnr-7-4-7 AJNR2019747 article Nadia Abd Al-Hamid Atitt-Allah 1 Rehab Mohammed Abd- Elhady 2 Ola Abdel-Wahab Afifi Araby Lolobody42012@yahoo.com 2 Maternity and Gynecological Health Nursing, Faculty of Nursing, Ain Shams University, Egypt Obstetrics and Woman Health Nursing, Faculty of Nursing, Benha University, Egypt Background: Human papillomavirus (HPV) is the commonest viral sexually transmitted infection in the world and the leading cause of cervical cancer. Aim: of this study was to evaluate the effect of educational intervention on knowledge and attitudes regarding human papillomavirus infection and its vaccination among nursing students. Design: Quasi-experimental design was utilized. Sample: A purposive sample of 200 female nursing students who registered in the first academic year at Faculty of Nursing Benha University. Setting: The study was carried out at Faculty of Nursing Benha University. Tools: Data were collected through two main tools: A self-administered questionnaire to assess students’ general characteristics and knowledge regarding HPV infection and its vaccination, and Modified Likert’s Scale to assess students’ attitude regarding HPV infection and its vaccination. Results: showed that the mean age of studied sample 17.87±0551years. There was improvement with highly statistically significant difference observed in students’ knowledge and attitude regarding HPV infection and its vaccination at post-intervention phase compared with pre-intervention phase (p<0.001). There was positive statistical correlation between total knowledge and total attitude regarding human papilloma virus infection and its vaccination at pre-intervention phase (P> 0.05). While, there was a highly positive statistical significant correlation between total knowledge and total attitude regarding human papilloma virus infection and its vaccination at post-intervention phase (p<0.001). Conclusion: The educational intervention enhanced student’s knowledge and positively changed their attitude regarding human papilloma virus infection and its vaccination. Recommendation: Dissemination of educational program among all female university students regarding human papilloma virus infection and vaccination to prevent the risk of infection and cervical cancer. http://pubs.sciepub.com/ajnr/7/4/7/ajnr-7-4-7.pdf human papillomavirus HPV education HPV vaccine HPV knowledge and attitudes cervical cancer