eng Science and Education Publishing American Journal of Nursing Research 2378-5586 2019-04-22 7 3 375 386 10.12691/ajnr-7-3-19 AJNR20197319 article Rasha Mohamed Hassan Eltelt m_r12008@yahoo.com 1 Manal Mansour Mostafa 2 Woman Health and Maternity Nursing, Faculty of Nursing Kafr El sheikh University, Egypt Community Health Nursing, Faculty of Nursing Fayom University, Egypt Mindfulness-based Cognitive therapy, theoretical and clinical work to working with mood concerns during pregnancy. Aim of this study was to evaluate the effect of the Mindfulness -based intervention Program on Stress Reduction during Pregnancy. Design: A quasi - experimental design was utilized in this study. Setting: The study was conducted in the obstetric outpatient clinics in Kafr El sheikh, University Hospital. Sample: A purposive sample was used for 100 pregnant women, who attained the above mentioned setting. Tools: three tools were used for data collection, interviewing questionnaire for assessing demographic characteristics for pregnant women. 2-perceived Stress Scale, 3 Mindful Attention Awareness Scale. Result: there are positive effects of mindfulness intervention program on the stress levels among studied mothers and the difference between stress scale levels pre and post intervention was highly significant (p=0.000). Conclusion this study concluded that women who learn mindfulness during pregnancy are likely to use those skills to mange stressful aspect of pregnancy, childbirth and parenting resulting in reductions in psychological distress and improvement in psychological well-being. Recommendation: Continuing mindfulness program about reduced stressful aspect of pregnancy, and researches are needed to detect the other problems to early management. http://pubs.sciepub.com/ajnr/7/3/19/ajnr-7-3-19.pdf mindfulness -based intervention program pregnant women and prenatal stress