eng Science and Education Publishing American Journal of Nanomaterials 2372-3122 2023-02-02 11 1 10 40 10.12691/ajn-11-1-2 AJN20231112 article Alireza Heidari 1 2 3 4 Roya Rahimi 5 Seyedeh Roghayeh Hosseini 5 Faculty of Chemistry, California South University, 14731 Comet St. Irvine, CA 92604, USA An Independent, Volunteer and Unaffiliated Researcher Considering the importance of oxadiazole derivatives as effective anti每cancer Nano drugs on cancer cells and various other therapeutic effects, in this research, the effect of new oxadiazole derivatives called 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in a solution. We studied the use of different spectroscopic methods. The present study investigated the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in laboratory conditions. The results show that the absorption rate of single每stranded DNA/RNA increases due to the interaction with 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole at 210 and 260 (nm) wavelengths. The emission spectrum of single每stranded DNA/RNA increases in a concentration每dependent trend of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole, which indicates the binding of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole with chromophores present in single每stranded DNA/RNA. The present study investigated the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in laboratory conditions. The results show that the absorption rate of single每stranded DNA/RNA increases due to the interaction with 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole at 210 and 260 (nm) wavelengths. The emission spectrum of single每stranded DNA/RNA increases in a process dependent on the concentration of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole, which indicates the binding of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole with chromophores present in single每stranded DNA/RNA. The results obtained from the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA can provide useful information in the field of designing anti每cancer Nano drugs with oxadiazole derivatives with more anti每tumor effect and less side effects. http://pubs.sciepub.com/ajn/11/1/2/ajn-11-1-2.pdf molecular dynamics simulation perception binding affinity performance nano synthesized DNA/RNA human cancer cells Biospectroscopic methods and techniques