@article{ajn20231112,
author={{Heidari, Alireza and Rahimi, Roya and Hosseini, Seyedeh Roghayeh},
title={Molecular Dynamics Simulation Perception Study of the Binding Affinity Performance for Nano Synthesized 3每(4每Chlorophenyl)每5每(4每Fluorophenyl)每4每Phenyl每4,5每Dihydro每1,2,4每Oxadiazole and 3,5每Bis每(4每Chlorophenyl)每4每Phenyl每4,5每Dihydro 1,2,4每Oxadiazole on DNA/RNA in Human Cancer Cells by Biospectroscopic Methods and Techniques},
journal={American Journal of Nanomaterials},
volume={11},
number={1},
pages={10--40},
year={2023},
url={http://pubs.sciepub.com/ajn/11/1/2},
issn={2372-3122},
abstract={Considering the importance of oxadiazole derivatives as effective anti每cancer Nano drugs on cancer cells and various other therapeutic effects, in this research, the effect of new oxadiazole derivatives called 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in a solution. We studied the use of different spectroscopic methods. The present study investigated the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in laboratory conditions. The results show that the absorption rate of single每stranded DNA/RNA increases due to the interaction with 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole at 210 and 260 (nm) wavelengths. The emission spectrum of single每stranded DNA/RNA increases in a concentration每dependent trend of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole, which indicates the binding of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole with chromophores present in single每stranded DNA/RNA. The present study investigated the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA in laboratory conditions. The results show that the absorption rate of single每stranded DNA/RNA increases due to the interaction with 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole at 210 and 260 (nm) wavelengths. The emission spectrum of single每stranded DNA/RNA increases in a process dependent on the concentration of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole, which indicates the binding of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole with chromophores present in single每stranded DNA/RNA. The results obtained from the effect of 3每(4每chlorophenyl)每5每(4每fluorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole and 3,5每bis每(4每chlorophenyl)每4每phenyl每4,5每dihydro每1,2,4每oxadiazole on single每stranded DNA/RNA can provide useful information in the field of designing anti每cancer Nano drugs with oxadiazole derivatives with more anti每tumor effect and less side effects. <img src=image/abs1.png></img>},
doi={10.12691/ajn-11-1-2}
publisher={Science and Education Publishing}
}