eng Science and Education Publishing American Journal of Medical Sciences and Medicine 2327-6657 2021-12-01 9 4 115 119 10.12691/ajmsm-9-4-4 AJMSM2021944 article Maximin Senou senouxim@yahoo.fr 1 Jacques Ez¨¦chiel Lokonon 1 Germaine Ayitchehou 1 F¨¦licienne Agbogba 1 2 Ren¨¦ J. Dehou 2 Esp¨¦rance Medoatinsa 2 Pascal Tchogou 2 Boris Fresel Cachon 2 Alban Houngbeme 3 Eug¨¨ne Attakpa 4 Am¨¨gnona Agbonon 5 Sa?d Lamine Baba-Moussa 6 Laboratory of Experimental and Clinical Biology (LaBEC), National School of Applied Biosciences and Biotechnologies (ENSBBA), National University of Sciences, Technologies, Engineering and Mathematics (UNSTIM), R. Benin Laboratoire National de Pharmacognosie/Centre B¨¦ninois de la Recherche Scientifique et Technique (CBRST). BP 06 Oganla Porto-Novo, R Benin Laboratoire de Physiopathologie Mol¨¦culaire et Toxicologie de la Facult¨¦ des Sciences et Techniques (FAST) de lˇŻUniversit¨¦ dˇŻAbomey-Calavi (UAC), R Benin Laboratoire de Physiologie/Pharmacologie, Facult¨¦ des Sciences, Universit¨¦ de Lom¨¦, R. Togo Laboratory of Biology and Molecular Typing in Microbiology, University of Abomey-Calavi 01 BP 188 Cotonou, R Benin All over the world, humans developed knowledge about the use of medicinal plants to treat all kinds of diseases. Spices were included. This work aimed to evaluate the hypoglycemic property Laurus nobilis, a spice used by traditional therapists in Benin for diabetes management. The aqueous extracts of the leaves of Laurus nobilis were obtained by maceration. The phytochemical screening was carried out. Acute oral toxicity tests by single dose gavage of 2000 mg / kg body weight were performed in female Wistar rats. The weight of the animals, the serum creatinine, the ALT transaminase and the hemoglobin level were determined on day 0 and then on day 14. For the efficacy test, the extract was administered to rats at a concentration of 300 mg / Kg of body weight for 21 consecutive days. The blood tests performed were blood sugar, triglycerides and cholesterol. Histological sections were taken from the liver, kidneys and spleen. The phytochemical screening revealed the presence of tannins, mucilages and flavonoids. There were no deaths of rats and their weights, blood creatinine, ALT transaminase, and hemoglobin levels did not vary significantly during the toxicity study, indicating no toxicity. Regarding the efficacy test, Laurus nobilis extract significantly lowered the mean blood sugar level in rats on day 14 and day 21 (P <0.05) while the mean triglyceride and cholesterol levels total did not significantly change during the experiment. Laurus nobilis displayed hypoglycemic properties in non-diabetic rats and was not acutely toxic. It could be used in the management of diabetes. http://pubs.sciepub.com/ajmsm/9/4/4/ajmsm-9-4-4.pdf Laurus nobilis hypoglycaemic acute toxicity Benin