@article{ajmsm2021944,
author={{Senou, Maximin and Lokonon, Jacques Ez¨¦chiel and Ayitchehou, Germaine and Agbogba, F¨¦licienne and Dehou, Ren¨¦ J. and Medoatinsa, Esp¨¦rance and Tchogou, Pascal and Cachon, Boris Fresel and Houngbeme, Alban and Attakpa, Eug¨¨ne and Agbonon, Am¨¨gnona and Baba-Moussa, Sa?d Lamine},
title={Antidiabetic Activity of Aqueous Extracts of <i>Laurus nobilis</i>, a Spice Used by Beninese Traditional Therapists},
journal={American Journal of Medical Sciences and Medicine},
volume={9},
number={4},
pages={115--119},
year={2021},
url={http://pubs.sciepub.com/ajmsm/9/4/4},
issn={2327-6657},
abstract={All over the world, humans developed knowledge about the use of medicinal plants to treat all kinds of diseases. Spices were included. This work aimed to evaluate the hypoglycemic property <i>Laurus nobilis</i>, a spice used by traditional therapists in Benin for diabetes management. The aqueous extracts of the leaves of <i>Laurus nobilis</i> were obtained by maceration. The phytochemical screening was carried out. Acute oral toxicity tests by single dose gavage of 2000 mg / kg body weight were performed in female Wistar rats. The weight of the animals, the serum creatinine, the ALT transaminase and the hemoglobin level were determined on day 0 and then on day 14. For the efficacy test, the extract was administered to rats at a concentration of 300 mg / Kg of body weight for 21 consecutive days. The blood tests performed were blood sugar, triglycerides and cholesterol. Histological sections were taken from the liver, kidneys and spleen. The phytochemical screening revealed the presence of tannins, mucilages and flavonoids. There were no deaths of rats and their weights, blood creatinine, ALT transaminase, and hemoglobin levels did not vary significantly during the toxicity study, indicating no toxicity. Regarding the efficacy test, <i>Laurus nobilis</i> extract significantly lowered the mean blood sugar level in rats on day 14 and day 21 (P &lt;0.05) while the mean triglyceride and cholesterol levels total did not significantly change during the experiment. <i>Laurus nobilis</i> displayed hypoglycemic properties in non-diabetic rats and was not acutely toxic. It could be used in the management of diabetes.},
doi={10.12691/ajmsm-9-4-4}
publisher={Science and Education Publishing}
}