eng Science and Education Publishing American Journal of Medical Sciences and Medicine 2327-6657 2018-11-09 6 2 45 50 10.12691/ajmsm-6-2-6 AJMSM2018626 article Ganiyat Oyeleke drgoyeleke@yahoo.com 1 Anele Ihekwaba 2 Lagos University Teaching Hospital, Lagos State, Nigeria University of Port Harcourt Teaching Hospital, Rivers State, Nigeria Background and Aims: The prevalence of People living with human Immunodeficiency virus remains considerably high in Nigeria. Liver disease has emerged as an increasingly significant contributor to mortality among HIV-infected patients. The aim of our study was to compare the difference in the prevalence of liver enzyme abnormalities between treatment naïve HIV positive and HIV negative patients. Method: The study was conducted at a teaching hospital. The study population consists of 736 patients (368 cases and 368 controls) that were selected from the hospital. The cases were treatment naïve HIV patients and the controls were patients being managed for other diseases. A diagnosis of liver disease was made based on the diagnostic criteria which include; presence of at least one clinical feature of liver disease, two liver chemistry abnormalities and an abnormal hepatic ultrasound report. Result: The mean ages of the cases and controls were 35.97±9.77 and 36.08±9.54 years respectively. Liver disease was seen in 277 (75.3%) of the cases and 54 (14.7%) of the controls, this difference was statistically significant (p<0.001). Alkaline phosphatase ALP (p<0.001) and Gamma-glutamyl transferase GGT (p=0.04) were indicative of the presence of liver diseases in univariate analysis. Although Bilirubin was not of statistical significance, all HIV infected patients with total bilirubin ≥ 25.5µmol/L had liver diseases. Conclusion: The use of abnormal liver enzymes and clinical features in resource poor settings are valuable screening tools to indicate the presence of liver diseases particularly in HIV ݨC infected patients. http://pubs.sciepub.com/ajmsm/6/2/6/ajmsm-6-2-6.pdf liver enzyme abnormalities HIV treatment na?ve HIV patients Nigeria