@article{ajmsm2017543,
author={{Aziz, Miriam Magdy and Fouad, Hala Mohammed Amin and H, Taher and Amin, Abdel Rahman Emam Sayed},
title={The Effect of Dopamine versus Norepinephrine on the Outcome of Pediatric Septic Shock},
journal={American Journal of Medical Sciences and Medicine},
volume={5},
number={4},
pages={79--90},
year={2017},
url={http://pubs.sciepub.com/ajmsm/5/4/3},
issn={2327-6657},
abstract={<b>Background:</b> Septic shock is a leading cause of mortality and morbidity among children all over the world. Vasoactive therapy must be initiated in patients who have not improved after fluid resuscitation. <b>Aim of work:</b> The aim of this study was to compare the effect of dopamine versus norepinephrine on the outcome of pediatric septic shock. <b>Patients and methods:</b> The study was a prospective observational study that was conducted on 40 children aged from 1 month to 12 years who were admitted to the emergency department. They were assigned by the treating physicians to two groups: 1) Group A: 20 patients who received dopamine (5-20 mcg/kg/min). 2) Group B: 20 patients who received norepinephrine (1-1.5 mcg/kg/min). Clinical, hemodynamic, and laboratory data were recorded and compared using appropriate statistical tests. <b>Results: </b>Baseline characteristics for the 40 children enrolled were nearly similar. There was a significantly higher mortality rate in the dopamine group compared with the norepinephrine one (P &lt; 0.05). As in the dopamine group, 15 patients died out of 20 patients, while in the norepinephrine group 8 patients died  out of 20 patients, (75% vs. 40%, p=0.025).<b> </b>Stepwise logistic regression analysis revealed that PRISM-24 (p=0.001), drug (p=0.019), and MODS (p=0.003) could independently predict the mortality in septic shock patients. <b>Conclusions:</b> Norepinephrine was associated with an increased response to treatment and decreased risk of death in children with septic shock as compared to dopamine. Dopamine, PRISM-24, and MODS could independently predict the mortality in children with septic shock.},
doi={10.12691/ajmsm-5-4-3}
publisher={Science and Education Publishing}
}