eng Science and Education Publishing American Journal of Medical Sciences and Medicine 2327-6657 2017-04-13 5 1 20 22 10.12691/ajmsm-5-1-3 AJMSM2017513 article Mazaher Ramezani 1 Farhad Kavousi 1 Setareh Afzali 2 Masoud Sadeghi Sadeghi_mbrc@yahoo.com 3 Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran Breast cancer constitutes a heterogenous group of lesions. Invasive papillary carcinoma of the breast is a rare form of breast cancer with less aggressive behavior which may have mucinous differentiation. Histologically papillary projections with fibrovascular core and epithelial proliferation are present. Signet ring morphology and extracellular mucin production can be seen but myoepithelial cells are absent. We reported a case of invasive papillary carcinoma of the breast in a 74-year-old lady without mucin production, which first presentation was a metastasis of unknown origin to the spinal column as adenocarcinoma with mucin production. In conclusion, although invasive papillary carcinoma of the breast is known as a less aggressive tumor, but its presentation may be with metastasis and mucin production, despite of non-mucinous primary tumor. http://pubs.sciepub.com/ajmsm/5/1/3/ajmsm-5-1-3.pdf invasive papillary carcinoma breast cancer mucinous adenocarcinoma metastasis