@article{ajmsm2014233,
author={{Kandi, Sabitha and Deshpande, Neelesh and Pinnelli, Venkata Bharath Kumar and Devaki, Ramakrishna and Rao, Pragna and Ramana, K V},
title={Alcoholism and Its Role in the Development of Oxidative Stress and DNA Damage: An Insight},
journal={American Journal of Medical Sciences and Medicine},
volume={2},
number={3},
pages={64--66},
year={2014},
url={http://pubs.sciepub.com/ajmsm/2/3/3},
issn={2327-6657},
abstract={Alcohol is detoxified in the liver by the enzymes alcohol dehydrogenase and aldehyde dehydrogenase. The available literature suggests that activity of aldehyde dehydrogenase is less than alcohol dehydrogenase among Asians; hence it leads to accumulation of acetaldehyde during excess intake of alcohol. Accumulated acetaldehyde due to its electrophilic nature forms adducts with proteins and DNA. The acetaldehyde-DNA adduct (N-2-Ethyl deoxyguanosine (NDG)) induces mutations in DNA and leads to DNA damage. Prevention of excessive accumulation of acetaldehyde can be useful in decreasing the genotoxicity.},
doi={10.12691/ajmsm-2-3-3}
publisher={Science and Education Publishing}
}