@article{ajmsm20261413,
author={{Alimov, D. A. and Mukhamedova, B. F. and Nazarova, M. Kh. and Kazakov, B. O. and Berdiev, N. F. and Kazakova, M. R.},
title={Determinants of Adverse Outcomes after Myocardial Infarction in Young Patients: A Clinico-Metabolic and Structural Analysis},
journal={American Journal of Medical Sciences and Medicine},
volume={14},
number={1},
pages={13--16},
year={2026},
url={https://pubs.sciepub.com/ajmsm/14/1/3},
issn={2327-6657},
abstract={Background. Myocardial infarction (MI) in young individuals is an increasingly recognized clinical problem associated with distinct risk factors and prognostic features. Aim. To evaluate clinical, metabolic, and structural-functional characteristics of MI in young patients and to identify predictors of adverse cardiovascular outcomes. Material and methods. A prospective cohort study included 108 young patients (18¨C45 years) with confirmed MI and 35 older patients (60¨C75 years). Clinical, laboratory, echocardiographic, and angiographic parameters were assessed at baseline and during a 12-month follow-up. The primary endpoint was a composite of major adverse cardiovascular events (MACE), including cardiovascular death, recurrent MI, unstable angina, and revascularization. Receiver operating characteristic (ROC) analysis and Kaplan¨CMeier survival analysis were performed. Results. Young patients were predominantly male (85.2%) and more frequently presented with ST-elevation MI (84.3%). Smoking was significantly more prevalent among young patients compared to older individuals (70.2% vs 20.6%, p<0.001), along with a higher prevalence of family history of early coronary artery disease. In contrast, hypertension and type 2 diabetes were more common in older patients. Coronary angiography demonstrated a higher prevalence of single-vessel disease in young patients (48.9% vs 26.7%, p=0.033), whereas multivessel disease predominated in the elderly group. At 12 months, MACE occurred in 24% of young patients, with a mortality rate of 3%. ROC analysis showed good predictive performance of selected parameters (AUC >0.70), while Kaplan¨CMeier analysis revealed significantly lower event-free survival in high-risk patients. Smoking, hypertension, and increased platelet aggregation were identified as independent predictors of adverse outcomes. Conclusion. Young MI patients exhibit a distinct clinical profile characterized by a high prevalence of modifiable risk factors and predominantly single-vessel coronary disease. Despite relatively favorable baseline characteristics, they remain at substantial risk of adverse cardiovascular outcomes. Aggressive risk factor modification and personalized long-term management strategies are essential to improve prognosis.},
doi={10.12691/ajmsm-14-1-3}
publisher={Science and Education Publishing}
}