eng Science and Education Publishing American Journal of Medical Sciences and Medicine 2327-6657 2023-11-15 11 4 98 101 10.12691/ajmsm-11-4-1 AJMSM20231141 article Hesham Mohamed Abdal-Salam Yehia heshamyehia@gmail.com 1 Said Mahmoud Said 2 Department of Biotechnology, HST Company, Cairo, Egypt Department of Biotechnology, HST Company Herpes simplex virus type 1 (HSV-1) is a member of the Herpesviridae family and is a common human pathogen. Herpes simplex virus type 1 (HSV-1) infection is a highly prevalent viral infection that affects a large portion of the population worldwide. The development of effective antiviral agents to combat HSV-1 is of great importance. In this study, we aimed to evaluate the efficacy of two potential antiviral candidates, OCTA-H and Octa-Gel, against HSV-1 infection. The assay was conducted using a BSC-III cabinet level 3 III under Germfree conditions to ensure accurate assessment of antiviral activity. The results demonstrated that both OCTA-H and Octa-Gel exhibited significant antiviral activity against HSV-1, with OCTA-H demonstrating a higher level of efficacy compared to Octa-Gel. These findings highlight the potential of OCTA-H as a promising candidate for further development as an antiviral agent against HSV-1. http://pubs.sciepub.com/ajmsm/11/4/1/ajmsm-11-4-1.pdf OCTA-H Octa-Gel HSV-1 antiviral activity efficacy