@article{ajms2014213,
author={{Salem, Abdel Halim and Ali, Muhalab and Ibrahim, Amir and Ibrahim, Mohamed},
title={Genotype and Allele Frequencies of <i>M</i><i>DR</i><i>-1</i> Gene Polymorphism in Jordanian and Sudanese Populations},
journal={American Journal of Medicine Studies},
volume={2},
number={1},
pages={19--23},
year={2014},
url={http://pubs.sciepub.com/ajms/2/1/3},
abstract={The aim of this study was to determine the genotype and allele frequencies of <i>MDR1</i> gene C3435T polymorphism in Jordanian and Sudanese populations, and to compare them with the frequencies established in various ethnic groups.<i><b> </b></i>Genotyping was carried out on 116 unrelated Jordanian and 131 Sudanese subjects. The genotypes of polymorphic position C3435T were determined by PCR-RFLP assay. Results showed that 20.7% of the studied Jordanian subjects were homozygous for the <i>CC</i> genotype, 51.7% were heterozygous for the <i>CT</i> genotype and 27.6% were homozygous for the <i>TT</i> genotype. Among Sudanese subjects, the genotype frequencies were: <i>CC</i> 52.7%, <i>CT</i> 42.0% and <i>TT</i> 5.3%. The frequencies of the <i>3435T</i> variant in the <i>MDR-1</i> Gene in Jordanians and Sudanese were found to be 0.534 and 0.263, respectively.<i><b> </b></i>According to the distribution of the C3435T SNP, Jordanians were resemble Asians and Europeans but were different significantly from Sudanese, while Sudanese were similar to Africans. In conclusion, the observed distribution of the C3435T SNP in the Jordanian and Sudanese populations was within the range detected in other populations. The data obtained may give the basis for predicting effects of drugs that are substrates for <i>MDR-1</i> in Jordanian and Sudanese populations and may be useful for individualized therapy of some diseases.},
doi={10.12691/ajms-2-1-3}
publisher={Science and Education Publishing}
}