@article{ajmr2021913,
author={{Amin, Sahar Saad Allah and Abdel-Aziz, Nada A. and El-Sayed, Wael S. and Mahmoud, Manal Ibrahim Hanafi and Elsayed, Eman Mohamed Sharaf and Eltahlawi, Rehab A.},
title={Evaluation of Resistant Urinary Tract Infections by Gram-positive Bacteria in Medina, Saudi Arabia},
journal={American Journal of Microbiological Research},
volume={9},
number={1},
pages={14--24},
year={2021},
url={http://pubs.sciepub.com/ajmr/9/1/3},
issn={2328-4137},
abstract={<b>Background</b>: Gram-positive uropathogens have become common, associated with serious underlying illnesses and increasingly resistant to available antibiotics. <b>Objectives</b>: The goal of this study was to investigate the incidence and risk factors of gram-positive cocci UTIs in hospitalized patients in Medina, KSA and their susceptibility patterns to widely used antimicrobial agents. <b>Methods</b>: During a 12-month study, 165 clinical isolates of gram-positive cocci were recovered from 1137 culture-positive urine specimens at a tertiary hospital. Antimicrobial susceptibility of gram-positive cocci isolates was tested with the disk diffusion and E test methods. Molecular typing of some VRE isolates was done to detect the predominant <i>Van</i> genotypes. <b>Results</b>: Out of 8600 reviewed cases, 1137 (13.2%) were culture positive, 165 cases (14.5%) were gram positive cocci. <i>E.faecalis</i> formed 53.3% (88/165) of isolated gram-positive cocci, followed by <i>E faecium </i>(17.6%), <i>S.agalactiae</i> (23.6%) and <i>S.</i> <i>aureus</i> (5.5%). Multidrug resistant positive cocci formed 9.7% of gram-positive isolates including VRE (8.5%) and MRSA (1.2%). 75% of <i>E. faecalis </i>and 50% of <i>E.</i><i> </i><i>faecium</i> isolates were sensitive to nitrofurantoin, all VRE strains were sensitive to linezolid. All <i>S. aureus</i> isolates were sensitive to cefazolin, nirtofurantoin, sulfamethoxazole and vancomycin. 75% of MRSA strains were sensitive to sulfamethoxazole and all were sensitive to vancomycin. All isolates of <i>S.</i><i> </i><i>agalactiae</i> were sensitive to cefazolin and nitrofurantoin, and all were resistant to Trimethoprim-sulfamethoxazole. <i>Van B</i> genotype was detected. <b>Conclusion</b>: Vancomycin and nitrofurantoin seem to be effective drugs for treatment of gram positive UTIs. <i>vanB</i> genotype was detected.},
doi={10.12691/ajmr-9-1-3}
publisher={Science and Education Publishing}
}