@article{ajmr2018624,
author={{Saha, Ritu and Ahmed, Sharmeen and Sattar, Humayun and Begum, Maksuma and Uddin, Bhuiyan Mohammad Mahtab and Saleh, Ahmed Abu and Miah, Ruhul Amin},
title={Association of <i>H.pylori cagA</i> Gene with Duodenal Ulcer &amp; Gastric Carcinoma in Bangladeshi Patients},
journal={American Journal of Microbiological Research},
volume={6},
number={2},
pages={57--62},
year={2018},
url={http://pubs.sciepub.com/ajmr/6/2/4},
issn={2328-4137},
abstract={<b>Background:</b> Prolong infection with <i>Helicobacter pylori</i> may lead to chronic inflammation of gastroduodenal mucosa which in turns develops into severe diseases like peptic ulcer and gastric carcinoma. Bacterial virulence factor Cytotoxin Associated gene (<i>cagA</i>) is found to be responsible for developing such severe diseases in different countries. So this study was conducted to assess the relationship between occurrence of several gastroduodenal diseases and the presence of <i>H. pylori cagA</i> gene in Bangladeshi patients. <b>Methods:</b> Endoscopic gastroduodenal biopsy sample of 113 dyspeptic patients from different districts of Bangladesh were studied. <i>H. pylori</i> infection was detected by Rapid urease test, PCR of <i>ureC</i> gene and histological staining (Geimsa). Gastroduodenal disease was diagnosed by histopathological examination and <i>cagA</i> gene was detected by PCR. <b>Result:</b> <i>H. pylori</i> infection was identified among 48% (54/113) patients. Fifty seven percent of <i>H. pylori</i> infected patients were found to be <i>cagA</i> gene positive. <i>cagA</i> gene is significantly associated with Duodenal ulcer (p= .024) and Gastric carcimoma (p &lt; .001). However, a further larger study is required to confirm this finding.},
doi={10.12691/ajmr-6-2-4}
publisher={Science and Education Publishing}
}