@article{ajmr2016422,
author={{Osman, Marwa Mohamed and Osman, Muataz Mohamed and Mohamed, Nihal Abdulla and Osman, Samah Mohamed and Magzoub, Mamoun and El-Sanousi, Suliman Mohamed},
title={Investigation on Vancomycin Resistance (VRSA) among Methicillin Resistant <i>S. aureus</i> (MRSA) in Khartoum State, Sudan},
journal={American Journal of Microbiological Research},
volume={4},
number={2},
pages={56--60},
year={2016},
url={http://pubs.sciepub.com/ajmr/4/2/2},
issn={2328-4137},
abstract={<b>Background: </b><i>Staphylococcus aureus</i><b> </b>is one of the most important and<b> </b>frequent cause of nosocomial infections worldwide. This study was carried out to investigate the prevalence of Vacomycin-Resistant <i>Staphylococcus aureus </i>and antibiotic sensitivity pattern in clinical<i> </i>isolates in Khartoum. <b>Methods:</b> One hundred and thirty three various samples were collected from some hospitals in Khartoum over a period of 5 months. The samples were cultured on bacteriological media for the isolation of <i>Staphylococcus aureus</i> using standard methods of isolation and identification of bacteria. The <i>Staphylococcus aureus</i> were tested for Methicillin susceptibility using 5 ¦Ìg Oxacillin disc and Oxacillin E-test, with Resistance defined as an MIC of ¡Ý 4¦Ìg/ ml. <b>Results: </b>In this study all MRSA isolates displayed an Oxacillin MIC of ¡Ý256¦Ìg/ml. The MRSA strains were 41.0% while the Resistance to vancomycin was examined by vancomycin E-test, with resistance defined as an MIC of ¡Ý16 ¦Ìg ml. In this study all VSSA isolates displayed vancomycin MIC of ¡Ü 2¦Ìg/ml "except three intermediate resistant isolate MIC between 4-8 ¦Ìg/ml". The percentage of the VISA strains was 12.0%. <b>Discussion:</b> The unprevalence of resistance to vancomycin may be related to the low usage of this antibiotic in this study area The majority MRSA isolates were multidrug-resistant (MDR) to different classes of antibiotics including; amoxicillin /clavulinic acid, ampicillin, tetracycline, erythromycin clindamycin and ciprofloxacin. Nitroforantoine exhibit no resistant pattern while 92% of MRSA isolates were susceptible to chloramphenicol. The unprevalence of resistance to Vancomycin may be related to the low usage of this antibiotic so Vancomycin might be used as a drug of choice for the treatment of MRSA infection.},
doi={10.12691/ajmr-4-2-2}
publisher={Science and Education Publishing}
}