@article{ajmr2015342,
author={{Pakadang, Sesilia Rante and Wahjuni, Chatarina Umbul and Notobroto, Hari Basuki and Winarni, Dwi and Dwiyanti, Ressy and Yadi, Y and Sabir, Muhammad and Hatta, Mochammad},
title={Immunomodulator Potential of Miana Leaves(<i>Coleus </i><i>s</i><i>cutellar</i><i>i</i><i>oides</i><i> </i>(L) Benth)<i> </i>in Prevention of Tuberculosis Infection},
journal={American Journal of Microbiological Research},
volume={3},
number={4},
pages={129--134},
year={2015},
url={http://pubs.sciepub.com/ajmr/3/4/2},
issn={2328-4137},
abstract={<b>Aim</b><b>,</b> The aim of this study to investigate the immunonomodulator effects of miana leaves (<i>Coleus </i><i>s</i><i>cutellar</i><i>i</i><i>oides</i><i> </i>(L) Benth) on prevention of tuberculosis in wistar rats<i>, </i><b>Method</b><b>,</b> Samples of white male Wistar rats were divided into 4 groups, the samples were treated with miana leaves extract (EDM) and then infected by intra tracheal <i>M. tuberculosis</i> H37Rv strain and subsequently given a placebo, EDM and GAB (combined Rifampicin and EDM) and healthy control animals were treated with EDM. In this study we measure the level of Immunomodulatory parameter; the number of T-lymphocytes and CD4 T-cells measured by flowcytometry method, the levels of IFN-¦Ã and TNF-¦Á were measured by ELISA and the number of <i>M. tuberculosis</i> colonies derived from the rat lung in LJ media. <b>Result</b><b>,</b> Results showed the increasing of T-lymphocytes, CD4 T-Cells, the levels of IFN-¦Ã, TNF-¦Á and decreasing in the number of <i>M. tuberculosis</i> colonies after EDM treatment. <b>Conclusion</b>, Miana leaves extract (Coleus scutellarioides, (L) Benth.) increased the number of T-lymphocytes, CD4 <i>T-cell</i> counts, levels of IFN-¦Ã and TNF-¦Á and decreased in the number of <i>M. tuberculosis</i> colony in infected wistar lung.},
doi={10.12691/ajmr-3-4-2}
publisher={Science and Education Publishing}
}