@article{ajmr20241244,
author={{Adams, Kofi Kobina Amandz¨¦ and St¨¦phane, Koffi Kouadio and Alexia, Yapi Ivane and Mourtada, Dine and Carole, Obouayeba Nguessan Djaman and Nathalie, Guessend and Mathieu, Kra Adou Koffi and Ad¨¨le, Kacou-N¡¯douba},
title={Prevalence and Characteristics of Intestinal Carriage of Multidrug-Resistant <i>Enterobacteriaceae</i> in Outpatients in Abidjan},
journal={American Journal of Microbiological Research},
volume={12},
number={4},
pages={98--105},
year={2024},
url={https://pubs.sciepub.com/ajmr/12/4/4},
issn={2328-4137},
abstract={<b>Background:</b> The growing threat of antibiotic resistance poses a major challenge to global public health as it could lead to up to 10 million deaths annually by 2050, particularly in low-income countries. The COVID-19 pandemic has further worsened the issue of multidrug-resistant bacteria, particularly extended-spectrum ¦Â-lactamase-producing <i>Enterobacteriaceae</i> (ESBL-PE). In Africa, data on intestinal carriage on ESBL-PE are scarce.<b> </b>This study aimed to assess the prevalence and risk factors associated with ESBL-PE intestinal carriage among outpatients at Treichville University Hospital. <b>Method: </b>This study was conducted from July to December 2023 at Treichville University Hospital. Rectal swabs were collected from patients attending the general medical consultation ward selected by systematic random sampling. <i>Enterobacteriaceae </i>strains were identified by conventional methods and antibiotic susceptibility testing was carried out in accordance with the CA-SFM EUCAST 2022 guidelines. Data were analysed using R studio software version 4.0.3. <b>Results: </b>Rate of intestinal carriage with resistance <i>Enterobacteriaceae </i>was 54.55%. Prevalence of ESBL-PE in intestinal carriage was 30.90%. Among ESBL-PE carriers, the predominant age group was between 40 years and older; with a sex ratio of 1.26 (55.88% male). <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> were the common ESBL producer species at 43.33% and 11.67% respectively. According to observed resistance patterns and predefined multidrug resistance categories, 94.60% of <i>Escherichia coli</i> strains and 100.00% of <i>Klebsiella pneumoniae</i> strains were identified as Multidrug-resistant. Only 5.40% of <i>Escherichia coli</i> strains were identified as Extensively drug-resistant. No isolates were classified as Pandrug- resistant. Risk factors like size of household living in a single room, presence of children under 15 years old, previous hospitalization (less than 6 months), antibiotic use (less than 3 months) and chronic medical diseases were significantly associated with ESBL-PE intestinal carriage (p&lt;0.05). <b>Conclusion:</b> High rate of ESBL-PE in intestinal carriage was observed. The knowledge of factors associated with Multi-resistant <i>Enterobacteriaceae</i> carriage helps to identify patients at risk to combat the spread of resistant bacteria within the healthcare system.},
doi={10.12691/ajmr-12-4-4}
publisher={Science and Education Publishing}
}