@article{ajmr20231133,
author={{Fatoumata, Kouakou Myrielle and Anatole, Toty Abal¨¦ and Victoire, Gadou and Val¨¦rie, MˇŻBengue Gbonon and Fernique, Konan Kouadio and Bertin, Gu¨¦d¨¦ Kipr¨¦ and Baguy, Ouattara Mohamed and Kouakou, Ti¨¦coura and Nathalie, Guessennd and Mireille, Dosso},
title={Detection of <i>qnr</i> Genes That Mediate Fluoroquinolone Resistance in Gram-Negative Bacilli in Abidjan, C?te d'Ivoire},
journal={American Journal of Microbiological Research},
volume={11},
number={3},
pages={79--82},
year={2023},
url={http://pubs.sciepub.com/ajmr/11/3/3},
issn={2328-4137},
abstract={<b>  </b>The public health threat of antimicrobial resistance remains a major challenge that keeps expanding as a result of the continuous dissemination of mobile genetic elements that mediate resistance among bacteria species. This study aimed to detect genetic determinants (<i>qnrA</i>, <i>qnrB</i>, <i>qnrC</i>, <i>qnrD</i>, <i>qnrS</i>, and <i>qnrVC</i> genes) that mediate fluoroquinolone resistance in Gram-negative bacilli in C?te d'Ivoire. A total of 30 strains were characterized by biochemical tests and their identity was confirmed by MALDI-TOF mass spectrometry. Antimicrobial susceptibility testing was performed by the agar diffusion method and the detection of qnr genes by polymerase chain reaction (PCR). Fifteen (57.7%) of the Enterobacteriaceae were extended-spectrum beta-lactamase (ESBL) producers. Susceptibility testing revealed resistance rates of 76.7%, 93.3%, 83.3%, and 65.2% for nalidixic acid, norfloxacin, ofloxacin, and levofloxacin respectively. Detection of fluoroquinolone resistance genes showed the presence of <i>qnrD</i> (36.7%), <i>qnrB</i> (36.7%), <i>qnrS</i> (13.3%), and <i>qnrA</i> (6.7%). This study is the first to demonstrate the presence of the qnrD gene in some Gram-negative bacilli in C?te d'Ivoire.},
doi={10.12691/ajmr-11-3-3}
publisher={Science and Education Publishing}
}