eng Science and Education Publishing American Journal of Microbiological Research 2328-4137 2023-02-27 11 1 14 18 10.12691/ajmr-11-1-2 AJMR20231112 article Ouattara Sitapha sitaphao@yahoo.fr 1 Ahon Gnamien Marcel 1 2 Kporou Kouassi Elis¨¦e 3 Bagre Issa 3 Soro Y¨¦d¨¦ D¨¦bora 3 Kra Adou Koffi Mathieu 3 Djaman Allico Joseph 3 4 Biology and Health Laboratory, Felix Houphouet-Boigny University, Cocody, Abidjan, Ivory Coast, 22 BP 582 Abidjan 22 Department of Biochemistry and Microbiology, Research Unit of Bioactive Natural Substances, Jean Lorougnon Guede University, Daloa, Ivory Coast, BP 150 Daloa Therapy by synthetic antimicrobial drugs is increasingly becoming limited by microbial resistance. As a possible remedy, antimicrobials from medicinal plants are being explored. The objective of this work was to compare the activities of extracts of Terminalia neotaliala capuron, oxacillin, and fluconazole on the in vitro growth of Staphylococcus aureus ATCC and Aspergillus niger. The evaluation was made by incorporating the hydroalcoholic extract of the plant (Combretaceae), oxacillin, and fluconazole using the oblique double dilution method with Sabouraud agar into wells cut into Petrie dishes. After 48 hours of incubation at 30? C, zones of inhibition were measured. Oxacillin had a greater zone of inhibition than the plant extract on Staphylococcus aureus ATCC for all concentrations. The zone of inhibition for fluconazole was lower than that of the extract on Aspergillus niger for the concentrations of 200 mg/mL and 100 mg/mL. The hydroethanolic extract of Terminalia neotaliala capuron inhibited the growth of Staphylococcus aureus ATCC and Aspergillus niger. http://pubs.sciepub.com/ajmr/11/1/2/ajmr-11-1-2.pdf Oxacillin fluconazole Terminalia neotaliala capuron Staphylococcus aureus ATCC Aspergillus niger