eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-04-25 9 8 397 401 10.12691/ajmcr-9-8-4 AJMCR2021984 article David Pisarcik dapisa@iu.edu 1 Gabriel Kousourou 2 Nagadarshini Vinod 2 Department of Medicine, Indiana University, Indianapolis, IN, USA Department of Rheumatology, Indiana University, Indianapolis, IN, USA Hypertrophic Osteoarthropathy (HOA) is a rare condition that presents with arthralgias, digital clubbing, and abnormal periosteal bone deposition seen on x rays. The secondary form of HOA may be associated with an underlying malignancy, thus highlighting the importance of early clinical recognition. We present the case of a 44-year-old woman who presented with several weeks of lower extremity swelling, arthralgias, and digital clubbing who was later found to have non-small cell lung cancer. Diagnosis can be challenging due to variable presentations that can often mimic other forms of inflammatory arthritis. Treatment is focused on addressing the underlying cause. Nonsteroidal anti-inflammatory drugs (NSAIDS) are commonly used for pain relief while intravenous bisphosphonates have been trialed with some success in case reports. http://pubs.sciepub.com/ajmcr/9/8/4/ajmcr-9-8-4.pdf paraneoplastic syndrome arthralgias clubbing periostosis hypertrophic osteoarthropathy