eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-03-31 9 7 345 347 10.12691/ajmcr-9-7-1 AJMCR2021971 article Eman EL-Sawalhy Eman.elsawalhy@beaumont.org 1 Muna Shaaeli 1 Wehbi Hnayni 1 Lubna Alattia 2 Shahina Patel 3 Department of Internal Medicine, Beaumont Hospital, Dearborn, MI Department of Clinical Pathology, Beaumont Hospital, Royal Oak, MI Division of Hematology & Oncology, Internal Medicine Department, Beaumont Hospital, Dearborn, MI Epithelioid Angiosarcoma (EA) is an extremely rare and highly aggressive malignant tumor. It comprises <1 % of all soft tissue sarcomas and is associated with a poor prognosis. In this case report, we are reporting an 85-years-old male who presented with lower back and left hip pain. A computerized tomography (CT) of the lumbar spine and left hip showed a significant fracture of lumbar spine L3 and osteolytic lesions involving the left hip and femur. The patient underwent L1-L5 fusion with cement augmentation and biopsy of L3. Surgical pathology showed a metastatic undifferentiated tumor of unknown primary origin. Histologic analysis of the specimen and immunohistochemistry confirmed EA. Given extensive diffuse bone involvement, our patient was not a candidate for definitive surgical treatment. http://pubs.sciepub.com/ajmcr/9/7/1/ajmcr-9-7-1.pdf Epithelioid Angiosarcoma bone surgical resection Tazemetostat