eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-03-18 9 6 318 320 10.12691/ajmcr-9-6-3 AJMCR2021963 article Raihane BAHRI raihanebahri01@gmail.com 1 2 Mohamed Amine AZNAG 2 3 Fadoua ELFARSSANI 3 3 Siham KHAYATI 3 3 Saida EDDYB 3 3 Hicham YAHYAOUI 3 3 Mustapha AIT AMEUR 3 3 Mohamed ZIANI 3 3 Mohamed CHAKOUR 3 3 Faculty of Medicine and Pharmacy, Marrakesh, Morocco Recurrent thrombosis is a common complication in various pathologies and is part of the definition of antiphospholipid syndrome. We report an observation in which the patient presented with repeated thrombosis, due not only to an antiphospholipid syndrome with partial thromboplastin time with normal activator, but also to a resistance to active protein C linked to the existence of the Leiden factor mutation V. This observation confirms the most often multifactorial nature of thromboses and therefore encourages the search for resistance to activated protein C before an evocative clinic, especially if the routine coagulation assessment is normal. http://pubs.sciepub.com/ajmcr/9/6/3/ajmcr-9-6-3.pdf leiden factor mutation V thrombosis antiphospholipid syndrome