eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-03-14 9 5 301 304 10.12691/ajmcr-9-5-11 AJMCR20219511 article Eman EL-Sawalhy Eman.elsawalhy@beaumont.org 1 Najlaa Al-Sudani 1 Wehbi Hnayni 1 Shahina Patel 2 Department of Internal medicine, Beaumont Hospital, Dearborn, MI Division of Hematology & Oncology, Internal Medicine Department, Beaumont Hospital, Dearborn, MI Immunoglobulin D (IgD) multiple Myeloma (MM) is a very rare subtype of myeloma. It accounts for only 1-2% of all MM patients. It is associated with a rapidly progressive disease and poorer outcomes compared with other MM subtypes. In this case report, we present a case of a sixty-year-old man who presented to our hospital with fatigue, anemia, thrombocytopenia, and acute renal failure. His bone marrow biopsy during admission showed 75.9% of plasma cells with significant light chain burden. He was also found to have severe immunoglobulin deficiency along with a lambda to kappa ratio was <0.01. The diagnosis of IgD MM was established, and he was started on CyBorD (Bortezomib, cyclophosphamide, and dexamethasone). Our patient also required hemodialysis for his kidney failure. http://pubs.sciepub.com/ajmcr/9/5/11/ajmcr-9-5-11.pdf Immunoglobulin D multiple myeloma renal failure light chain nephropathy CyBorD