eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-01-27 9 4 229 231 10.12691/ajmcr-9-4-6 AJMCR2021946 article Hammam Shereef 1 Mohamedanwar Ghandour mr.anwar90@yahoo.com 2 Sarah Abdelsamad 2 Ahmed Subahi 3 Ahmed S Yassin 3 Luis Afonso 3 Department of Internal Medicine, Beaumont Hospital-Dearborn, Michigan, USA Division of Nephrology, Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA Division of Cardiovascular Medicine, Department of Internal Medicine, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA Propafenone is a Class 1 C anti-arrhythmic drug, frequently used in the treatment of supraventricular and ventricular arrhythmias. We herein are presenting a case of 67-year-old female who presented with wide complex tachycardia consistent with Propafenone toxicity and who responded immediately to sodium bicarbonate injections. This case shines the light on a common effect of Propafenone toxicity and aims to increase the clinician awareness about such a documented reaction, that can be reversed by a simple treatment like sodium bicarbonate. http://pubs.sciepub.com/ajmcr/9/4/6/ajmcr-9-4-6.pdf propafenone tachycardia atrial fibrillation