eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-02-04 9 4 263 267 10.12691/ajmcr-9-4-15 AJMCR20219415 article Andrew V. Doodnauth 1 Ahmad Jallad 2 Dahlia Rizk 3 Emmanuel Valery 3 Samy I. McFarlane Smcfarlane@downstte.edu 3 Department of Internal Medicine, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203 Division of Cardiovascular Medicine, Electrophysiology Section, State University of New York: Downstate Medical Center, Brooklyn, New York, United States- 11203 Division of Hospital Medicine, Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine NY, NY 10003 COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is associated with significant cardiovascular dysfunction in patients with, and without, pre-existing cardiovascular disease [1]. There are now well-documented cardiac complications of COVID-19 infection which include myocarditis, heart failure, and acute coronary syndrome [2]. There is growing evidence showing that arrhythmias are also one of the major complications of COVID-19. We report a patient with no known cardiac conduction disease who presented with syncope, positive SARS-CoV-2 PCR, who was persistently bradycardic and subsequently developed sinus node dysfunction (SND). To date, there are a limited number of reports of sinus node dysfunction (SND) associated with COVID-19. We describe the clinical characteristics, potential pathophysiologic mechanisms and management of COVID-19 patients who experienced de novo SND. http://pubs.sciepub.com/ajmcr/9/4/15/ajmcr-9-4-15.pdf COVID-19 SARS-CoV-2 bradycardic sinus node dysfunction (SND)