@article{ajmcr2021941,
author={{Shereef, Hammam and Ghandour, Mohamedanwar and Mustafa, Mohamed and Hashim, Ahmed and Rahal, Omar Nasser and Powers, Jeremy and Elteriefi, Ruaa and Musa, Faisal},
title={Cancer of the Grave: A Rapidly Growing Anaplastic Thyroid Cancer with NRAS and TP53 Mutation: Molecular Understanding and Therapeutic Hopes},
journal={American Journal of Medical Case Reports},
volume={9},
number={4},
pages={208--212},
year={2021},
url={http://pubs.sciepub.com/ajmcr/9/4/1},
issn={2374-216X},
abstract={Anaplastic thyroid cancer (ATC) is the rarest form of thyroid cancer known to humans. Among the other thyroid neoplasms, ATC is the deadliest, with unified mortality of almost 100%. With the advances in thyroid ultrasounds and screening protocols, the incidence of ATC increases, which correlates with the increase in papillary thyroid cancer (PTC) that is believed to be the precursor of most ATC. We herein describe a rare case of a 69-year-old Caucasian male with no known past medical or surgical histories who presented with a rapidly growing neck mass that was later confirmed as an undifferentiated anaplastic thyroid carcinoma with a mutation in NRAS and TP53 progressing in two months period into a complete seeding of lungs with metastasis. This case highlights the importance of studying and understanding thyroid oncogenesis's molecular aspects as recently targeted immunotherapy is promising for particular gene mutations by delaying this graving cancer progression.},
doi={10.12691/ajmcr-9-4-1}
publisher={Science and Education Publishing}
}