eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-01-13 9 3 167 169 10.12691/ajmcr-9-3-9 AJMCR2021939 article Mohamedanwar Ghandour mr.anwar90@yahoo.com 1 Ahmed Abdalrahem 2 Hammam Shereef 3 Yahya Osman-Malik 3 Hillel Sternlicht 3 Department of Internal Medicine- Division of Nephrology, Wayne State University Department of internal medicine, Wayne State University Department of internal medicine, Beaumont Health System Waldenström's macroglobulinemia (WM) is a rare cancer of the lymphatic system due to excess IgM monoclonal protein with a rare renal involvement. We describe a case of MW presenting with acute renal failure. A 63-year-old female who was admitted to our hospital for influenza B complicated by acute renal failure during the hospital stay, with creatinine up to 6 mg/dL, despite adequate hydration. Electrophoresis revealed a monoclonal component in the gamma region, which was classified as an IgM k. A kidney biopsy was performed, showing light cast chains suggested the possibility of myeloma kidney. Furthermore, bone marrow histology was performed, revealing lymphoplasmacytic lymphoma. The patient was treated with bortezomib, dexamethasone, and cyclophosphamide, with complete recovery of renal function (creatinine 1.1 mg/dL). http://pubs.sciepub.com/ajmcr/9/3/9/ajmcr-9-3-9.pdf Waldenstr?m's macroglobulinemia light cast chain nephropathy