eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-01-13 9 3 163 166 10.12691/ajmcr-9-3-8 AJMCR2021938 article Gil Hevroni 1 Diego Cepeda-Mora 1 Zachary Mostel 1 Luis Lugo 1 Samy I McFarlane smcfarlane@downstate.edu 1 Department of Internal Medicine, SUNY-Downstate Health Science University, Brooklyn, New York, USA11203 While patients with severe COVID-19 infection often have cardiovascular comorbidities, there is a paucity of literature outlining the potential of this novel coronavirus to trigger acute decompensated heart failure. To date, there is limited understanding of the pathophysiology of heart failure in COVID-19; some suggest decompensation is a result of an incident episode of myocarditis as seen with other respiratory viruses. Here we present a case of a 25 year old man with no known cardiovascular disease, who presented with acute decompensated heart failure found to have an ejection fraction of ten percent in the setting of COVID-19 infection and subsequently had multiple admissions for heart failure decompensation. An extensive work-up was performed and ruled out cardiovascular and rheumatological causes of heart failure, making COVID-19 infection a plausible etiologic factor for heart failure. http://pubs.sciepub.com/ajmcr/9/3/8/ajmcr-9-3-8.pdf heart failure COVID-19 SARS-CoV-2 myocarditis cardiovascular disease