eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-12-20 9 2 131 133 10.12691/ajmcr-9-2-8 AJMCR2021928 article Louis Costanzo louis.costanzo@downstate.edu 1 Chetana Pendkar 1 Amara Shafi 1 Joseph Gorga 2 Department of Internal Medicine, State University of New York, Downstate- Health Science University, Brooklyn, NY, USA - 11203 Division of Pulmonology, State University of New York, Downstate- Health Science University, Brooklyn, NY, USA - 11203 Patients taking antipsychotic medications have a well-established increased risk of developing metabolic syndrome. These medications interfere with an intracellular signaling pathway leading to insulin resistance; that of which can lead to dangerous complications including diabetic ketoacidosis (DKA) and severe hypertriglyceridemia. We report a case of a 21-year-old man who developed DKA and severe hypertriglyceridemia secondary to the use of olanzapine used for the management of schizophrenia. http://pubs.sciepub.com/ajmcr/9/2/8/ajmcr-9-2-8.pdf atypical antipsychotics critical care diabetic ketoacidosis hypertriglyceridemia insulin resistance metabolic acidosis olanzapine