eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-09-09 9 12 693 697 10.12691/ajmcr-9-12-8 AJMCR20219128 article Humaira Nasir 1 Nida Saleem nidasaa1968@gmail.com 2 Fatima Anwar 2 Rabia Saleem 2 Syed Nayer Mahmud 2 Pathology Department, Shifa International Hospital, Islamabad, 00000, Pakistan Nephrology Department, Shifa International Hospital, Islamabad, 00000, Pakistan Karyomegalic interstitial nephritis (KIN) is a rare cause of hereditary interstitial nephritis, described 45 years ago. Only about 50 cases have been described in English literature so far and none from Pakistan. This disease has an escalated course with a worsened outcome. There are a few potential mimickers of this disease both clinically and histologically, which might lead to a missed diagnosis and hence poor management. We have described here a series of 05 cases of KIN that were diagnosed at our institute for better understanding of this disease entity. http://pubs.sciepub.com/ajmcr/9/12/8/ajmcr-9-12-8.pdf interstitial nephritis karyomegalic interstitial nephritis chronic kidney disease histopathology kidney transplantation