eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-10-13 9 12 730 733 10.12691/ajmcr-9-12-18 AJMCR202191218 article Kami Whitney PA-C kamirenee@gmail.com 1 Arjun Medical Center, Gainesville, VA, USA Mucus hypersecretion is a debilitating feature of COPD that is often overlooked and under treated by clinicians despite its contribution to declining lung function and quality of life. This case study explores the use of the COPD Assessment Test in the evaluation of mucus hypersecretion and improvements in quality of life related to this symptom after the addition of guaifenesin as part of a comprehensive COPD care plan. http://pubs.sciepub.com/ajmcr/9/12/18/ajmcr-9-12-18.pdf COPD exacerbation mucus hypersecretion mucociliary clearance guaifenesin chronic bronchitis