eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-07-18 9 11 544 547 10.12691/ajmcr-9-11-7 AJMCR20219117 article Rachel Russell 1 Walid Omer 2 Nagat Mudabal 2 Karolyn A. Wanat kwanat@mcw.edu 3 Medical College of Wisconsin, Milwaukee, United States Department of Nephrology, Medical College of Wisconsin, Milwaukee, United States Department of Dermatopathology, Medical College of Wisconsin, Milwaukee, United States Calciphylaxis is a rare condition in which calcification of medium blood vessels in the skin results in the purpura and painful, necrotic skin ulcers. Although most commonly seen in adults with end-stage kidney disease and long-term dialysis use, reports of nonuremic calciphylaxis exist. We present the case of a 29-year old woman with recently diagnosed end-stage liver disease who presented with an acute kidney injury and painful lower extremity purpura and ulcers with biopsy-confirmed calciphylaxis. The patient had been receiving dialysis for less than one month. Treatment with sodium thiosulfate was provided but was unsuccessful. The patient ultimately pursued palliative care. http://pubs.sciepub.com/ajmcr/9/11/7/ajmcr-9-11-7.pdf calciphylaxis end-stage liver disease acute kidney injury