eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2021-06-03 9 10 489 491 10.12691/ajmcr-9-10-2 AJMCR20219102 article Kourosh Shargani Kshargani@northwell.edu 1 Danielle Sherlock 1 Cheng-Hung Tai 1 Harry Fischer 1 Northwell Lenox Hill Hospital, New York, NY. 100 E 77th St, New York, NY 10075, USA Reactive Arthritis, formerly known as Reiter¡¯s syndrome, is a delayed autoimmune mediated inflammatory reaction in the joints that occurs from a response to an infection elsewhere in the body. It usually occurs in young males in response to a genitourinary or gastrointestinal infection. These males may have a predisposition to reactive arthritis by being Human Leukocyte Antigen-B27 (HLA-B27) positive. This report will display an unusual case of reactive arthritis in an elderly female. http://pubs.sciepub.com/ajmcr/9/10/2/ajmcr-9-10-2.pdf reactive arthritis reiter¡¯s syndrome Clostridium Difficile HLA-B27 Arthritis elderly staph aureus MRSA