eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-11-12 9 1 71 74 10.12691/ajmcr-9-1-18 AJMCR20219118 article Simin Laiq siminlaiq@hotmail.com 1 Jaragh M 2 Ginsberg H 3 David G Munoz 3 Histopathology Department, Directorate General of Khoula Hospital, Muscat, Oman Division of Pathology, St. Michael¡¯s Hospital, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada Division of Neurosurgery, St. Michael¡¯s Hospital, Department of Surgery, Toronto, Ontario, Canada Medulloblastoma with myogenic differentiation (MMD), previously termed medullomyoblastoma, is a distinctive subtype of medulloblastoma. It is an uncommon neoplasm in children and very rare in adults, with oldest reported case being 49-years of age. We present a case of large cell/anaplastic medulloblastoma with myogenic differentiation arising in the right cerebellar hemisphere of a 54-year-old man treated by surgical resection and radiotherapy. Despite C-MYC amplification in the tumor, he survived tumor-free for nearly 2 years (726 days), which greatly exceeded the expected total survival. His death was attributed to complications of treatment rather than recurrence. http://pubs.sciepub.com/ajmcr/9/1/18/ajmcr-9-1-18.pdf Large cell/anaplastic medulloblastoma with myogenic differentiation medullomyoblastoma cerebellum adult C-MYC amplification