eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-11-12 9 1 67 70 10.12691/ajmcr-9-1-17 AJMCR20219117 article Huang Zhou 1 Xue Kuang 1 Xianbin Lan 2 Huaan Du 2 Wenjiang Chen 2 Zulong Xie 2 Yuehui Yin yinyh63@163.com 2 #These authors contributed equally to this work. Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, China In some cases, Empty sella syndrome (ESS) is associated with pituitary deficiency. Although it is well known that pituitary hormones have effects on in many organs and systems, few studies have addressed the relationship between hypopituitarism and heart/arrhythmia. This unusual situation leads to discussion of the possible causes and management. We present a case of a 19-year-old male with an onset of cardiac arrhythmia was finally diagnosed as hypopituitarism. The patient recovered quickly by the means of hydrocortisone therapy. Most of pituitary hormones returned to normal, as well as no ventricular arrhythmia occurred any more. Good outcomes were observed that suggesting pituitary hormones may have effects on cardiac conduction system. However, the exact mechanisms need to be further studied. http://pubs.sciepub.com/ajmcr/9/1/17/ajmcr-9-1-17.pdf Empty Sella Syndrome hypopituitarism cardiac arrhythmia