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Asymptomatic Patient with an Uncommonly Located Myxoma in the Left Ventricle Attached to Chordae Tendinae

Jonathan Francois, Eric Kupferstein, Rishard Abdul, Joseph Casillas, Ishmam Ibtida, Moro Salifu, Samy I. McFarlane*

Department of Internal Medicine and Division of Cardiovascular Medicine, Department of Medicine. SUNY Downstate- Health Science University, Brooklyn, New York, United States- 11203

Abstract: Cardiac tumors are rare disorders with an incidence of <0.33%. Primary cardiac tumors are extremely rare with an incidence between 0.0017% and 0.19%. Nearly 75% of cardiac tumors are benign with atrial myxomas representing nearly 50%. The majority of cardiac myxomas (75%) are located in the left atrium, 23% in right atrium and 2% in the ventricular cavity. This report presents a rare case of an asymptomatic patient with a left ventricular myxoma attached to the chordae tendinae of the mitral valve.

Keywords: myxoma, left ventricle, cardiac tumor, chordae tendinae

Received May 02, 2020; Revised June 04, 2020; Accepted June 11, 2020

Citation: Jonathan Francois, Eric Kupferstein, Rishard Abdul, Joseph Casillas, Ishmam Ibtida, Moro Salifu, Samy I. McFarlane, Asymptomatic Patient with an Uncommonly Located Myxoma in the Left Ventricle Attached to Chordae Tendinae. American Journal of Medical Case Reports, 8 (9). 313-314. January 2020. doi:10.12691/ajmcr-8-9-14

1. Introduction

Cardiac tumors are rare disorders with an incidence rate <0.33%. They can be classified as primary or secondary depending on the origins of the tumor [1]. Primary cardiac tumors make 5% whereas secondary cardiac tumors represent 95% of all cardiac tumors [2]. Approximately 75% of cardiac neoplasms are considered benign; of these, about 50% are myxomas [3]. The majority of cardiac myxomas (75%) are located in the left atrium, 23% in right atrium and 2% in the ventricular cavity [4]. These tumors usually arise from the fossa ovalis of the inte-ratrial septum [5].

This report presents a rare case of a left ventricular myxoma attached to the chordae tendinae of the mitral valve.

2. Case

A 58-year-old male with a past medical history of prostate cancer, hypertension and end stage renal disease on hemodialysis presented to the clinic for cardiac evaluation as a kidney transplant candidate. Patient was asymptomatic with a blood pressure of 112/63 mmHg and heart rate of 87 beats per minute. The physical examination was pertinent for grade I/VI mid-diastolic murmur at the cardiac apex and lower extremity 2+ pitting edema. The transthoracic echocardiogram revealed an ejection fraction of 60-65%, no regional wall abnormalities and a small circular mass (measured ~ 0.8 cm) that appeared to be attached to the chordae tendinae of the mitral valve. This mass was not apparent on previous studies. A transesophageal echocardiography was subsequently performed, which showed a 0.9 x 0.8 cm myxoma which appeared to be stemming from the chordae tendinae of the mitral valve (Figure 1 & Figure 2). He was subsequently referred to cardiothoracic surgery for excision and biopsy but was unable to undergo the procedure given his active cancer.

Figure 1. Trans-esophageal echocardiogram showing 0.9 x 0.8 cm mass

Figure 2. Attached to chordeae tendinea

3. Discussion

Cardiac tumors have an incidence of <0.33% [1] with primary cardiac tumors being exceptionally rare, with an incidence between 0.0017% and 0.19% [6]. Nearly 75% of them are benign and half of the benign tumors are myxomas. The rest are mostly lipomas, papillary fibroelastomas, and rhadomyomas [7]. Nearly 90% of myxomas are located in atria, most of them arise from fossa ovalis along the interatrial septum [7]. A very small percentage of myxomas are detected in the left or right ventricle (only 3 to 4 percent per each ventricle) [7]. Our patient was diagnosed with a left ventricular myxoma attached to the chordae tendinae of the mitral valve; only one other case has been published with a similar diagnosis [8].

The clinical findings of myxomas are determined by their size, location and mobility. The symptoms can present as a triad of embolic phenomena, intracardiac obstruction, or constitutional symptoms [7] with most patients being symptomatic.. In our case report, the patient was totally asymptomatic with no history of systemic embolism, cardiac obstruction or constitutional symptoms. Systemic embolism is the most common complication of a left ventricular (LV) myxoma, and is seen in up to 50% of cases [9]. In the majority of cases, the cerebral arteries, including the retinal arteries, are affected [9]. Left ventricular myxomas may lead to valvular obstruction mimicking the clinical presentation of mitral stenosis. It could also lead to obstruction of the left ventricular outflow tract [7,9]. Myxomas may also present with systemic symptoms such as night sweats, fever, weight loss and symptoms of connective tissue disorders [10].

The diagnosis of cardiac tumors can be performed by multiple modalities; echocardiogram is the most commonly used as it has a high sensitivity and specificity for the diagnosis, particularly of cardiac myxomas [5]. Transesophageal echocardiogram provides more detailed evaluation, such as the site of insertion and the morphological features, and is more accurate at detecting small tumors (1 to 3 mm in diameter) compared to transthoracic echocardiogram [5].

The treatment of choice for myxomas is surgical removal, which should be done promptly because of the risk of embolic complications and sudden cardiac death [7]. In our patient with active prostate cancer, this treatment option was deferred.

Acknowledgements

This work is supported, in part, by the efforts of Dr. Moro O. Salifu M.D., M.P.H., M.B.A., M.A.C.P., Professor and Chairman of Medicine through NIH Grant number S21MD012474.

References

[1]   | Ren DY, Fuller ND, Gilbert SAB, Zhang Y. Cardiac Tumors: Clinical Perspective and Therapeutic Considerations. Curr Drug Targets 2017; 18: 1805-1809.
[2]   | Matsui Y, Shiiya N, Murashita T, Yasuda K. Myxoma of the mitral valve prolapsing into the left atrium and ventricle: report of a case. Surg Today 1998; 28: 1105-7.
[3]   | Wold LE, Lie JT. Cardiac myxomas: a clinicopathologic profile. Am J Pathol 1980; 101: 219-40.
[4]   | Meng Q, Lai H, Lima J, Tong W, Qian Y, Lai S. Echocardiographic and pathologic characteristics of primary cardiac tumors: a study of 149 cases. Int J Cardiol 2002; 84: 69-75.
[5]   | Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR. Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. Radiographics 2000; 20: 1073-103; quiz 1110-1, 1112.
[6]   | Petris AO, Alexandrescu DM, Costache, II. Cardiac tumors. Rev Med Chir Soc Med Nat Iasi 2014; 118: 289-92.
[7]   | Reynen K. Cardiac myxomas. N Engl J Med 1995; 333: 1610-7.
[8]   | Ozkan B, Sahin DY, Koc M, Uysal OK, Tekin K, Cayli M. A case of unusually located left ventricular myxoma: myxoma attached to the chordae tendinea of the mitral valve. J Echocardiogr 2011; 9: 165-6.
[9]   | Thongcharoen P, Laksanabunsong P, Thongtang V. Left ventricular outflow tract obstruction due to a left ventricular myxoma: a case report and review of the literature. J Med Assoc Thai 1997; 80: 799-806.
[10]   | Endo A, Ohtahara A, Kinugawa T, Ogino K, Hisatome I, Shigemasa C. Characteristics of cardiac myxoma with constitutional signs: a multicenter study in Japan. Clin Cardiol 2002; 25: 367-70.