eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-06-08 8 9 306 310 10.12691/ajmcr-8-9-12 AJMCR20208912 article Michael Trevisonno michael.trevisonno@downstate.edu 1 Daniel E. Diaz 2 Steven S. Chin 3 FCAP Jenny Libien 3 Yamen Homsi 4 Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, USA Department of Pathology, State University of New York Downstate Medical Center, Brooklyn, USA Therapath Neuropathology, New York, USA Department of Rheumatology, New York University Langone Hospital, Brooklyn, USA Antisynthetase Syndrome is a rare type of idiopathic inflammatory myopathy. It is characterized by interstitial lung disease, non-erosive arthritis, Raynaud¡¯s phenomenon, and mechanic¡¯s hands. Diagnosis is confirmed with the detection of an antibody directed against amino-acyl transferase RNA. Opportunistic infections are common causes of mortality in patients with autoimmune diseases. Immunosuppressive treatment further contributes to the risk of infection. We report, for the first time in the literature, a 62-year-old woman diagnosed with Anti-EJ antisynthestase syndrome who died from disseminated mycobacterial tuberculosis infection. This case emphasizes the importance of early recognition and prompt treatment of opportunistic infections in order to decrease mortality. http://pubs.sciepub.com/ajmcr/8/9/12/ajmcr-8-9-12.pdf antisynthetase syndrome Anti-EJ antibody idiopathic inflammatory myopathy mycobacterium tuberculosis