eng Science and Education Publishing American Journal of Medical Case Reports 2374-216X 2020-04-16 8 7 182 184 10.12691/ajmcr-8-7-5 AJMCR2020875 article Anoceto Mart¨ªnez A 1 Ruiz Hern¨¢ndez JJ jjruiher@gmail.com 1 2 Mohamad Tubio M 3 Gonz¨¢lez Pinedo L 4 Internal Medicine Department, Hospital Universitario de Gran Canaria ¡°Dr Negr¨ªn¡±, Las Palmas, Spain Department of Radiology, Hospital Universitario de Gran Canaria ¡°Dr Negr¨ªn¡±, Las Palmas, Spain Department of Hematology, Hospital Universitario de Gran Canaria ¡°Dr Negr¨ªn¡±, Las Palmas, Spain Gastric cancer (GC) is still the second most common cause of cancer-related death worldwide. In addition, gastric cancer is the most commonly diagnosed malignancy in Korea, Japan, China, South America and Eastern European nations, with the lowest frequency observed in the United States and Canada. Metastatic gastric cancer is a therapeutic challenge for medical oncologists, especially those with bone marrow metastases. Bone marrow metastases occur in many solid tumors such as breast, lung, prostate and gastric cancer [1]. Our case is about a woman diagnosed of gastric adenocarcinoma with signet ring cells presenting with bone marrow infiltration. http://pubs.sciepub.com/ajmcr/8/7/5/ajmcr-8-7-5.pdf gastric cancer signet ring cell bone marrow metastasis; lytic bone metastasis